RT Journal Article
T1 AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.
A1 Casado, Jorge
A1 Iñigo-Chaves, Almudena
A1 Jimenez-Ruiz, Sergio M
A1 Rios-Arrabal, Sandra
A1 Carazo-Gallego, Angel
A1 Gonzalez-Puga, Cristina
A1 Nuñez, Maria Isabel
A1 Ruiz-Extremera, Angeles
A1 Salmeron, Javier
A1 Leon, Josefa
K1 cancer stem cells
K1 colorectal cancer
K1 melatonin
K1 metastasis
K1 p53
AB The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. p53 loss increases the pool of CSCs in colorectal cancer (CRC). Recent reports suggest that the oncostatic effects of melatonin could be related to its ability to kill CSCs. Although there are no data linking the loss of p53 function and melatonin synthesis or signaling in cancer, melatonin does activate the p53 tumor-suppressor pathway in this disease. In this work, we analyze whether the expression of melatonin synthesis and signaling genes are related to the expression of CSC markers and the implication of p53 status in samples from patients with CRC. Arylalkylamine N-acetyltransferase (AA-NAT), MT1, and MT2 expression decreased in tumor samples versus normal mucosa samples in mutated p53 (mtp53) tumors versus those with wild-type p53 (wtp53). Further, AA-NAT and MT2 expression were lower in advanced stages of the disease in wtp53 tumors. On the contrary, CD44 and CD66c expression was higher in tumor versus normal mucosa in wtp53 tumors. Additionally, CD44 expression was higher in advanced stages of the disease regardless of the p53 status. Patients with CD44highCD66chigh and wtp53 tumors in advanced stages showed low expression of AA-NAT and MT2 in wtp53 tumors. These results could indicate a possible interaction of these pathways in CRC.
PB MDPI AG
YR 2017
FD 2017-06-07
LK http://hdl.handle.net/10668/11295
UL http://hdl.handle.net/10668/11295
LA en
NO Casado J, Iñigo-Chaves A, Jiménez-Ruiz SM, Ríos-Arrabal S, Carazo-Gallego Á, González-Puga C, et al. AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors. Int J Mol Sci. 2017 Jun 11;18(6):1251.
NO This research was supported by grants from the Consejería de Salud de la Junta de Andalucía (PI-0677-2013). Josefa León acknowledges sponsorship from the Servicio Andaluz de Salud “Nicolás Monardes” program.
DS RISalud
RD Apr 19, 2025