RT Journal Article
T1 Infant Immune Response to Respiratory Viral Infections.
A1 Heinonen, Santtu
A1 Rodriguez-Fernandez, Rosa
A1 Diaz, Alejandro
A1 Oliva Rodriguez-Pastor, Silvia
A1 Ramilo, Octavio
A1 Mejias, Asuncion
K1 Adaptive immune response
K1 Innate immunity
K1 RSV
K1 Rhinovirus
AB Of all respiratory viruses that affect infants, respiratory syncytial virus (RSV) and rhinovirus (RV) represent the leading pathogens causing acute disease (bronchiolitis) and are associated with the development of recurrent wheezing and asthma. The immune system in infants is still developing, and several factors contribute to their increased susceptibility to viral infections. These factors include differences in pathogen detection, weaker interferon responses, lack of immunologic memory toward the invading pathogen, and T-cell responses that are balanced to promote tolerance and restrain inflammation. These aspects are reviewed here with a focus on RSV and RV infections.
YR 2019
FD 2019-05-15
LK http://hdl.handle.net/10668/14227
UL http://hdl.handle.net/10668/14227
LA en
DS RISalud
RD Apr 6, 2025