RT Journal Article
T1 Natural and Induced Tolerance to Hymenoptera Venom: A Single Mechanism?
A1 Navas, Ana
A1 Ruiz-Leon, Berta
A1 Serrano, Pilar
A1 Marti, Manuel
A1 Espinazo, M Luisa
A1 Blanco, Nadine
A1 Molina, Juan
A1 Alonso, Corona
A1 Jurado, Aurora
A1 Moreno-Aguilar, Carmen
K1 Helios protein
K1 Anaphylaxis
K1 Bee venom immunotherapy
K1 Kynurenine
K1 Tolerance
AB Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy to bee stings. In order to increase the existing knowledge on the underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, a group of 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year of BVIT. In addition, the results of treated patients with those of an untreated group of 20 tolerant beekeepers (TG) who had previously shown a firm suppressor-regulatory profile were compared. Tolerance in AG patients was invariably associated with a significant regulatory response characterised by the expansion of Helios- subpopulation and increased IL-10, specific IgG4 (sIgG4), and kynurenine levels. Although specific IgE (sIgE) levels increased transiently, surprisingly, the T helper type 2 (Th2) population and IL-4 levels rose significantly after one year of immunotherapy. Thus, the picture of two parallel phenomena emerges: a tolerogenic response and an allergenic one. Comparing these results with those obtained from the TG, different immunological mechanisms appear to govern natural and acquired tolerance to immunotherapy. Of particular interest, the kynurenine levels and T regulatory (Treg) Helios- population could be proposed as new biomarkers of response to BVIT.
PB MDPI
YR 2022
FD 2022-06-17
LK http://hdl.handle.net/10668/21593
UL http://hdl.handle.net/10668/21593
LA en
NO Navas A, Ruiz-Leon B, Serrano P, Martí M, Espinazo ML, Blanco N, et al. Natural and Induced Tolerance to Hymenoptera Venom: A Single Mechanism? Toxins (Basel). 2022 Jun 22;14(7):426
DS RISalud
RD Apr 10, 2025