RT Journal Article
T1 Predictive factors of renal impairment in HIV-infected patients on antiretroviral therapy: Results from the VACH longitudinal cohort study.
A1 Domingo, Pere
A1 Suarez-Lozano, Ignacio
A1 Gutierrez, Félix
A1 Estrada, Vicente
A1 Knobel, Hernando
A1 Palacios, Rosario
A1 Antela, Antonio
A1 Blanco, José-Ramón
A1 Fulladosa, Xavier
A1 VACH, 
K1 Ageing
K1 Diabetes
K1 Disfunción renal
K1 Envejecimiento
K1 España
K1 Fumarato de disoproxilo de tenofovir
K1 Hipertensión
K1 Human immunodeficiency virus
K1 Hypertension
K1 Insuficiencia renal
K1 Renal impairment
K1 Renal insufficiency
K1 Spain
K1 Tenofovir
K1 Tenofovir disoproxil fumarate
K1 Virus de la inmunodeficiencia humana
AB The use of combination antiretroviral therapy has led to dramatic improvements in the life expectancy of HIV-infected persons. As result, the HIV population is aging and increasingly facing illnesses typically seen in the elderly, such as chronic kidney disease (CKD). A retrospective longitudinal study was conducted using data from years 2010 and 2014 in all HIV-infected persons enrolled at the Spanish VACH cohort. We analyzed the prevalence and the predictive factors for developing CKD (estimated glomerular filtration rate, eGFR The CKD prevalence at baseline was 456/8968, 5.1% [4.6-5.6%]. Of 8512 HIV-positive individuals examined without CKD at baseline (73.7% male, median age 44 years-old), 2.15% developed CKD (eGFR The prevalence and risk factors for CKD and its progression are high in the VACH cohort. Thus, preventive measures such as control of hypertension, diabetes and obesity, as well as efforts for avoiding exposure to nephrotoxic drugs, including some antiretrovirals, are warranted in this aging HIV population.
YR 2019
FD 2019-04-24
LK http://hdl.handle.net/10668/13882
UL http://hdl.handle.net/10668/13882
LA en
LA es
DS RISalud
RD Apr 7, 2025