RT Journal Article
T1 Nanostructured fibrin agarose hydrogel as a novel haemostatic agent.
A1 Campos-Cuerva, Rafael
A1 Fernandez-Muñoz, Beatriz
A1 Farfan Lopez, Francisco
A1 Pereira Arenas, Sheila
A1 Santos-Gonzalez, Monica
A1 Lopez-Navas, Luis
A1 Alaminos, Miguel
A1 Campos, Antonio
A1 Muntane, Jordi
A1 Cepeda-Franco, Carmen
A1 Gomez-Bravo, Miguel Angel
K1 bleeding
K1 fibrin agarose hydrogel
K1 fibrin sealant
K1 haemostasis
K1 haemostatic agent
K1 liver resection
K1 nanostructured biomaterial
K1 surgery
AB Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical haemostatic agents to overcome this issue therefore becomes necessary. Fibrin sealants are promising haemostatic agents due to their capacity to promote coagulation, but their effectiveness and applicability need to be improved. We have compared the haemostatic efficacy of a novel nanostructured fibrin-agarose hydrogel patch, with (c-NFAH) or without cells (a-NFAH), against two commercially available haemostatic agents in a rat model of hepatic resection. Hepatic resections were performed by making short or long incisions (mild or severe model, respectively), and haemostatic agents were applied to evaluate time to haemostasis, presence of haematoma, post-operative adhesions to adjacent tissues, and inflammation factors. We found a significantly higher haemostatic success rate (time to haemostasis) with a-NFAH than with other commercial haemostatic agents. Furthermore, other relevant outcomes investigated were also improved in the a-NFAH group, including no presence of haematoma, lower adhesions, and lower grades of haemorrhage, inflammation, and necrosis in histological analysis. Overall, these findings identify a-NFAH as a promising haemostatic agent in liver resection and likely in a range of surgical procedures.
PB Hindawi Limited
YR 2019
FD 2019-02-21
LK http://hdl.handle.net/10668/13608
UL http://hdl.handle.net/10668/13608
LA en
NO Campos-Cuerva R, Fernández-Muñoz B, Farfán López F, Pereira Arenas S, Santos-González M, Lopez-Navas L, et al. Nanostructured fibrin agarose hydrogel as a novel haemostatic agent. J Tissue Eng Regen Med. 2019 Apr;13(4):664-673.
DS RISalud
RD Apr 19, 2025