RT Journal Article
T1 Group B streptococcal haemolysin and pigment, a tale of twins.
A1 Rosa-Fraile, Manuel
A1 Dramsi, Shaynoor
A1 Spellerberg, Barbara
K1 Streptococcus agalactiae
K1 Group B streptococcus
K1 GBS
K1 Hemolysin
K1 Pigment
K1 Granadaene
K1 Proteínas bacterianas
K1 Proteínas hemolisinas
K1 Familia de multigenes
K1 Operón
K1 Pigmentos biológicos
K1 Infecciones estreptocócicas
K1 Factores de virulencia
K1 Animales
AB Group B streptococcus [(GBS or Streptococcus agalactiae)] is a leading cause of neonatal meningitis and septicaemia. Most clinical isolates express simultaneously a β-haemolysin/cytolysin and a red polyenic pigment, two phenotypic traits important for GBS identification in medical microbiology. The genetic determinants encoding the GBS haemolysin and pigment have been elucidated and the molecular structure of the pigment has been determined. The cyl operon involved in haemolysin and pigment production is regulated by the major two-component system CovS/R, which coordinates the expression of multiple virulence factors of GBS. Genetic analyses indicated strongly that the haemolysin activity was due to a cytolytic toxin encoded by cylE. However, the biochemical nature of the GBS haemolysin has remained elusive for almost a century because of its instability during purification procedures. Recently, it has been suggested that the haemolytic and cytolytic activity of GBS is due to the ornithine rhamnopolyenic pigment and not to the CylE protein. Here we review and summarize our current knowledge of the genetics, regulation and biochemistry of these twin GBS phenotypic traits, including their functions as GBS virulence factors.
PB Oxford University Press
SN 0168-6445
YR 2014
FD 2014-09
LK http://hdl.handle.net/10668/2378
UL http://hdl.handle.net/10668/2378
LA en
NO Rosa-Fraile M, Dramsi S, Spellerberg B. Group B streptococcal haemolysin and pigment, a tale of twins. FEMS Microbiol Rev. 2014; 38(5):932-46
NO Journal Article; Review;
DS RISalud
RD Apr 9, 2025