RT Journal Article
T1 Distinct spectral dynamics of implanted cardiac defibrillator signals in spontaneous termination of polymorphic ventricular tachycardia and fibrillation in patients with electrical and structural diseases.
A1 Calvo, David
A1 Salinas, Lucia
A1 Martínez-Camblor, Pablo
A1 García-Iglesias, Daniel
A1 Alzueta, Javier
A1 Rodríguez, Anibal
A1 Romero, Rafael
A1 Viñolas, Xavier
A1 Fernández-Lozano, Ignacio
A1 Anguera, Ignasi
A1 Villacastín, Julián
A1 Bodegas, Andrés
A1 Fontenla, Adolfo
A1 Jalife, José
A1 Berenfeld, Omer
K1 Polymorphic ventricular tachycardia • Ventricular fibrillation • Implanted cardiac defibrillators • Arrhythmogenic substrate • Spectral analysis • Dominant frequency • Regularity index
AB To determine the spectral dynamics of early spontaneous polymorphic ventricular tachycardia and ventricular fibrillation (PVT/VF) in humans. Fifty-eight self-terminated and 173 shock-terminated episodes of spontaneously initiated PVT/VF recorded by Medtronic implanted cardiac defibrillators (ICDs) in 87 patients with various cardiac pathologies were analyzed by short fast Fourier transform of shifting segments to determine the dynamics of dominant frequency (DF) and regularity index (RI). The progression in the intensity of DF and RI accumulations further quantified the time course of spectral characteristics of the episodes. Episodes of self-terminated PVT/VF lasted 8.6 s [95% confidence interval (CI): 8.1-9.1] and shock-terminated lasted 13.9 s (13.6-14.3) (P  Consistent with the notion that fast organized sources maintain PVT/VF in humans, reduction of frequency and regularity correlates with early self-termination. Our findings might help generate ICD methods aiming to reduce inappropriate shock deliveries.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/19777
UL http://hdl.handle.net/10668/19777
LA en
DS RISalud
RD Apr 18, 2025