RT Journal Article
T1 Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors.
A1 Herrera-Martinez, Yiraldine
A1 Contreras Gonzalez, María Jose
A1 Pedraza-Arevalo, Sergio
A1 Guerrero Martinez, Maria Del Carmen
A1 Rodrigo Martinnez, Angela
A1 Gonzalez Menchen, Alberto
A1 Blanco Molina, Maria Angeles
A1 Galvez-Moreno, Maria Angeles
A1 Moreno-Vega, Alberto L
A1 Luque, Raul M
A1 Herrera-Martinez, Aura D
K1 GIST tumor
K1 Calcitriol
K1 Corticoids
K1 Hypercalcemia
K1 Somatostatin receptors
AB Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal stromal tumors (GIST). We present a case report of a female patient with a 23 cm gastric GIST that expressed somatostatin-receptors and presented with severe hypercalcemia due to calcitriol secretion. Calcium control was achieved with medical treatment before the use of targeted-directed therapies. Surgery was performed and allowed complete tumor resection. Two years later, patient remains free of disease. Molecular analysis revealed the mRNA expression of 25-hydroxyvitamin D3-1-hydroxylase (1αOHase) and vitamin-D receptors in the tumor cells, confirming the calcitriol-mediated mechanism. Furthermore, the expression of the endotoxin recognition factors CD14 and TLR4 suggests an inflammatory mediated mechanism. Finally, the expression of somatostatin-receptors, especially SST2 might have been related with clinical evolution and prognosis in this patient.
PB Frontiers Research Foundation
SN 1664-2392
YR 2021
FD 2021-12-23
LK http://hdl.handle.net/10668/20556
UL http://hdl.handle.net/10668/20556
LA en
NO Herrera-Martínez Y, Contreras González MJ, Pedraza-Arévalo S, Guerrero Martínez MDC, Rodrigo Martínez Á, González Menchen A, et al. Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors. Front Endocrinol (Lausanne). 2022 Jan 26;12:812385
DS RISalud
RD Apr 7, 2025