%0 Journal Article
%A Herrera-Martinez, Yiraldine
%A Contreras Gonzalez, María Jose
%A Pedraza-Arevalo, Sergio
%A Guerrero Martinez, Maria Del Carmen
%A Rodrigo Martinnez, Angela
%A Gonzalez Menchen, Alberto
%A Blanco Molina, Maria Angeles
%A Galvez-Moreno, Maria Angeles
%A Moreno-Vega, Alberto L
%A Luque, Raul M
%A Herrera-Martinez, Aura D
%T Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors.
%D 2021
%@ 1664-2392
%U http://hdl.handle.net/10668/20556
%X Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal stromal tumors (GIST). We present a case report of a female patient with a 23 cm gastric GIST that expressed somatostatin-receptors and presented with severe hypercalcemia due to calcitriol secretion. Calcium control was achieved with medical treatment before the use of targeted-directed therapies. Surgery was performed and allowed complete tumor resection. Two years later, patient remains free of disease. Molecular analysis revealed the mRNA expression of 25-hydroxyvitamin D3-1-hydroxylase (1αOHase) and vitamin-D receptors in the tumor cells, confirming the calcitriol-mediated mechanism. Furthermore, the expression of the endotoxin recognition factors CD14 and TLR4 suggests an inflammatory mediated mechanism. Finally, the expression of somatostatin-receptors, especially SST2 might have been related with clinical evolution and prognosis in this patient.
%K GIST tumor
%K Calcitriol
%K Corticoids
%K Hypercalcemia
%K Somatostatin receptors
%~