RT Journal Article
T1 Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
A1 Azaryah, Hatim
A1 Verdejo-Román, Juan
A1 Martin-Pérez, Cristina
A1 García-Santos, José Antonio
A1 Martínez-Zaldívar, Cristina
A1 Torres-Espínola, Francisco J.
A1 Campos, Daniel
A1 Koletzko, Berthold
A1 Pérez-García, Miguel
A1 Catena, Andrés
A1 Campoy, Cristina
K1 Fish oil
K1 Folate
K1 Pregnancy
K1 Brain function
K1 Resting-state functional neuroimaging
K1 Neurodevelopment
K1 Children
K1 Maternal nutritional physiological phenomena
K1 Aceites de pescado
K1 Ácido fólico
K1 Embarazo
K1 Niño
K1 Fenómenos fisiologicos nutricionales maternos
AB Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children's brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5-10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided into groups according to mother's supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE < 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother's FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´s cognitive processing.
PB MDPI
YR 2020
FD 2020-09-04
LK http://hdl.handle.net/10668/4058
UL http://hdl.handle.net/10668/4058
LA en
NO Azaryah H, Verdejo-Román J, Martin-Pérez C, García-Santos JA, Martínez-Zaldívar C, Torres-Espínola FJ, et al. Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial. Nutrients. 2020 Sep 4;12(9):2701
DS RISalud
RD Apr 8, 2025