RT Journal Article
T1 The Role of BANK1 in B Cell Signaling and Disease
A1 Gómez Hernández, Gonzalo
A1 Morell, Maria
A1 Alarcón-Riquelme, Marta E.
K1 B cells
K1 B cell receptor
K1 CD40
K1 Autoimmunity
K1 Genetic association
K1 B cell scaffold with ankyrin repeats
K1 TLR7
K1 BLK
K1 LYN
K1 TRAF6
K1 Células B
K1 Antígenos CD40
K1 Autoinmunidad
K1 Asociación genética
AB The B cell scaffold protein with ankyrin repeats (BANK1) is expressed primarily in B cells and with multiple but discrete roles in B cell signaling, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. The gene for BANK1, located in chromosome 4, has been found to contain genetic variants that are associated with several autoimmune diseases and also other complex phenotypes, in particular, with systemic lupus erythematosus. Common genetic variants are associated with changes in BANK1 expression in B cells, while rare variants modify their capacity to bind efferent effectors during signaling. A BANK1-deficient model has shown the importance of BANK1 during TLR7 and TLR9 signaling and has confirmed its role in the disease. Still, much needs to be done to fully understand the function of BANK1, but the main conclusion is that it may be the link between different signaling functions within the B cells and they may act to synergize the various pathways within a cell. With this review, we hope to enhance the interest in this molecule.
PB MDPI
YR 2021
FD 2021-05-12
LK http://hdl.handle.net/10668/3880
UL http://hdl.handle.net/10668/3880
LA en
NO Gómez Hernández G, Morell M, Alarcón-Riquelme ME. The Role of BANK1 in B Cell Signaling and Disease. Cells. 2021 May 12;10(5):1184
DS RISalud
RD Apr 11, 2025