RT Journal Article
T1 Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis.
A1 Hidalgo-Tenorio, Carmen
A1 Galvez, Juan
A1 Martinez-Marcos, Francisco Javier
A1 Plata-Ciezar, Antonio
A1 De-La-Torre-Lima, Javier
A1 Lopez-Cortes, Luis Eduardo
A1 Noureddine, Mariam
A1 Reguera, Jose M
A1 Vinuesa, David
A1 Garcia, Maria Victoria
A1 Ojeda, Guillermo
A1 Luque, Rafael
A1 Lomas, Jose Manuel
A1 Lepe, Jose Antonio
A1 de-Alarcon, Arístides
K1 Endocarditis
K1 Methicillin resistance
K1 Staphylococcus aureus
K1 Vancomycin
AB S. aureus (SA) infective endocarditis (IE) has a very high mortality, attributed to the age and comorbidities of patients, inadequate or delayed antibiotic treatment, and methicillin resistance, among other causes. The main study objective was to analyze epidemiological and clinical differences between IE by methicillin-resistant versus methicillin-susceptible SA (MRSA vs. MSSA) and to examine prognostic factors for SA endocarditis, including methicillin resistance and vancomycin minimum inhibitory concentration (MIC) values > 1 μg/mL to MRSA. Patients with SA endocarditis were consecutively and prospectively recruited from the Andalusia endocarditis cohort between 1984 and January 2017. We studied 437 patients with SA endocarditis, which was MRSA in 13.5% of cases. A greater likelihood of history of COPD (OR 3.19; 95% CI 1.41-7.23), invasive procedures, or recognized infection focus in the 3 months before IE onset (OR 2.9; 95% CI 1.14-7.65) and of diagnostic delay (OR 3.94; 95% CI 1.64-9.5) was observed in patients with MRSA versus MSSA endocarditis. The one-year mortality rate due to SA endocarditis was 44.3% and associated with decade of endocarditis onset (1985-1999) (OR 8.391; 95% CI (2.82-24.9); 2000-2009 (OR 6.4; 95% CI 2.92-14.06); active neoplasm (OR 6.63; 95% CI 1.7-25.5) and sepsis (OR 2.28; 95% CI 1.053-4.9). Methicillin resistance was not associated with higher IE-related mortality (49.7 vs. 43.1%; p = 0.32). MRSA IE is associated with COPD, previous invasive procedure or recognized infection focus, and nosocomial or healthcare-related origin. Methicillin resistance does not appear to be a decisive prognostic factor for SA IE.
PB BioMed Central
YR 2020
FD 2020-02-21
LK http://hdl.handle.net/10668/15145
UL http://hdl.handle.net/10668/15145
LA en
NO Hidalgo-Tenorio C, Gálvez J, Martínez-Marcos FJ, Plata-Ciezar A, De La Torre-Lima J, López-Cortés LE, et al. Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis. BMC Infect Dis. 2020 Feb 21;20(1):160
DS RISalud
RD Apr 19, 2025