RT Journal Article T1 Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function: The 2-Year Longitudinal Changes in an Older Spanish Cohort. A1 Nishi, Stephanie K A1 Babio, Nancy A1 Gómez-Martínez, Carlos A1 Martínez-González, Miguel Ángel A1 Ros, Emilio A1 Corella, Dolores A1 Castañer, Olga A1 Martínez, J Alfredo A1 Alonso-Gómez, Ángel M A1 Wärnberg, Julia A1 Vioque, Jesús A1 Romaguera, Dora A1 López-Miranda, José A1 Estruch, Ramon A1 Tinahones, Francisco J A1 Lapetra, José A1 Serra-Majem, J Luís A1 Bueno-Cavanillas, Aurora A1 Tur, Josep A A1 Martín Sánchez, Vicente A1 Pintó, Xavier A1 Delgado-Rodríguez, Miguel A1 Matía-Martín, Pilar A1 Vidal, Josep A1 Vázquez, Clotilde A1 Daimiel, Lidia A1 Razquin, Cristina A1 Coltell, Oscar A1 Becerra-Tomás, Nerea A1 De La Torre Fornell, Rafael A1 Abete, Itziar A1 Sorto-Sanchez, Carolina A1 Barón-López, Francisco Javier A1 Signes-Pastor, Antonio José A1 Konieczna, Jadwiga A1 Garcia-Rios, Antonio A1 Casas, Rosa A1 Gomez-Perez, Ana Maria A1 Santos-Lozano, José Manuel A1 García-Arellano, Ana A1 Guillem-Saiz, Patricia A1 Ni, Jiaqi A1 Trinidad Soria-Florido, Maria A1 Zulet, M Ángeles A1 Vaquero-Luna, Jessica A1 Toledo, Estefanía A1 Fitó, Montserrat A1 Salas-Salvadó, Jordi K1 DASH diet K1 MIND diet K1 Mediterranean diet (MedDiet) K1 cognition K1 dietary pattern AB Background and Aims: Plant-forward dietary patterns have been associated with cardiometabolic health benefits, which, in turn, have been related to cognitive performance with inconsistent findings. The objective of this study was to examine the relationship between baseline adherence to three a priori dietary patterns (Mediterranean, DASH, and MIND diets) with 2-year changes in cognitive performance in older adults with overweight or obesity and high cardiovascular disease risk. Methods: A prospective cohort analysis was conducted within the PREDIMED-Plus trial, involving 6,647 men and women aged 55-75 years with overweight or obesity and metabolic syndrome. Using a validated, semiquantitative 143-item food frequency questionnaire completed at baseline, the dietary pattern adherence scores were calculated. An extensive neuropsychological test battery was administered at baseline and 2-year follow-up. Multivariable-adjusted linear regression models were used to assess associations between 2-year changes in cognitive function z-scores across tertiles of baseline adherence to the a priori dietary patterns. Results: Adherence to the Mediterranean diet at baseline was associated with 2-year changes in the general cognitive screening Mini-Mental State Examination (MMSE, β: 0.070; 95% CI: 0.014, 0.175, P-trend = 0.011), and two executive function-related assessments: the Trail Making Tests Part A (TMT-A, β: -0.054; 95% CI: -0.110, - 0.002, P-trend = 0.047) and Part B (TMT-B, β: -0.079; 95% CI: -0.134, -0.024, P-trend = 0.004). Adherence to the MIND diet was associated with the backward recall Digit Span Test assessment of working memory (DST-B, β: 0.058; 95% CI: 0.002, 0.114, P-trend = 0.045). However, higher adherence to the DASH dietary pattern was not associated with better cognitive function over a period of 2 years. Conclusion: In older Spanish individuals with overweight or obesity and at high cardiovascular disease risk, higher baseline adherence to the Mediterranean dietary pattern may be associated with better cognitive performance than lower adherence over a period of 2 years. SN 1663-4365 YR 2021 FD 2021-12-13 LK https://hdl.handle.net/10668/25676 UL https://hdl.handle.net/10668/25676 LA en DS RISalud RD Apr 6, 2025