TY  - JOUR
AU  - Rao, Zhigang
AU  - Caprioglio, Diego
AU  - Gollowitzer, Andre
AU  - Kretzer, Christian
AU  - Imperio, Daniela
AU  - Collado, Juan A
AU  - Waltl, Lorenz
AU  - Lackner, Sandra
AU  - Appendino, Giovanni
AU  - Muñoz, Eduardo
AU  - Temml, Veronika
AU  - Werz, Oliver
AU  - Minassi, Alberto
AU  - Koeberle, Andreas
PY  - 2022
DO  - 10.1016/j.bcp.2022.115202
UR  - http://hdl.handle.net/10668/22029
T2  - Biochemical pharmacology
AB  - Polypharmacological targeting of lipid mediator networks offers potential for efficient and safe anti-inflammatory therapy. Because of the diversity of its biological targets, curcumin (1a) has been viewed as a privileged structure for bioactivity or,...
LA  - en
PB  - Elsevier
KW  - Curcumin
KW  - Inflammation
KW  - Leukotriene
KW  - Lipid mediators
KW  - Natural product
KW  - Structure–activity relationship
KW  - Arachidonate 5-lipoxygenase
KW  - Constriction
KW  - Curcumin
KW  - Diarylheptanoids
KW  - Eicosanoids
KW  - Humans
KW  - Leukotrienes
KW  - Lipoxygenase inhibitors
KW  - Macrophages
KW  - Molecular docking simulation
KW  - Prostaglandin-E synthases
KW  - Prostaglandins
TI  - Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.
TY  - research article
VL  - 203
ER  -