TY  - JOUR
AU  - Ho, Ya-Hsuan
AU  - Del Toro, Raquel
AU  - Rivera-Torres, José
AU  - Rak, Justyna
AU  - Korn, Claudia
AU  - García-García, Andrés
AU  - Macías, David
AU  - González-Gómez, Cristina
AU  - Del Monte, Alberto
AU  - Wittner, Monika
AU  - Waller, Amie K
AU  - Foster, Holly R
AU  - López-Otín, Carlos
AU  - Johnson, Randall S
AU  - Nerlov, Claus
AU  - Ghevaert, Cedric
AU  - Vainchenker, William
AU  - Louache, Fawzia
AU  - Andrés, Vicente
AU  - Méndez-Ferrer, Simón
PY  - 2019
DO  - 10.1016/j.stem.2019.06.007
UR  - https://hdl.handle.net/10668/27543
T2  - Cell stem cell
AB  - Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated. Megakaryocytes promote quiescence of...
LA  - en
KW  - Hutchinson-Gilford progeria
KW  - aging
KW  - hematopoietic stem cell
KW  - lymphoid
KW  - microenvironment
KW  - myeloid
KW  - niche
KW  - Adrenergic Agonists
KW  - Aging
KW  - Aging, Premature
KW  - Animals
KW  - Bone Marrow
KW  - Cell Differentiation
KW  - Cell Encapsulation
KW  - Cell Proliferation
KW  - Disease Models, Animal
KW  - Hematopoietic Stem Cells
KW  - Humans
KW  - Interleukin-6
KW  - Megakaryocytes
KW  - Mice
KW  - Myeloid Cells
KW  - Nitric Oxide Synthase Type I
KW  - Progeria
KW  - Receptors, Adrenergic, beta-2
KW  - Signal Transduction
KW  - Stem Cell Niche
TI  - Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
TY  - research article
VL  - 25
ER  -