RT Journal Article
T1 Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine.
A1 Martinez-Moreno, D
A1 Jimenez, G
A1 Galvez-Martin, P
A1 Rus, G
A1 Marchal, J A
K1 Biomechanics
K1 Mechanotransduction
K1 Osteoarthritis
K1 Regenerative medicine
K1 Tissue engineering
K1 Ultrasound
AB Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular matrix (ECM); and its role in OA development. The ECM of the articular cartilage (AC) is widely involved in cartilage turnover processes being crucial in regeneration and joint diseases. We also review the importance of physicochemical pathways following the external forces in AC. Moreover, new techniques probed in cartilage tissue engineering for biomechanical stimulation are reviewed. The final objective of these novel approaches is to create a cellular implant that maintains all the biochemical and biomechanical properties of the original tissue for long-term replacements in patients with OA.
PB Elsevier BV
YR 2019
FD 2019-03-20
LK http://hdl.handle.net/10668/13757
UL http://hdl.handle.net/10668/13757
LA en
NO Martínez-Moreno D, Jiménez G, Gálvez-Martín P, Rus G, Marchal JA. Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1067-1075.
NO Part of this work was supported by the Ministerio de Economía, Industria y Competitividad (FEDER funds, projects RTC-2016-5451-1, DPI2017-83859-R, DPI2014-51870-R, and UNGR15-CE-3664) and from the Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (FEDER funds, DTS17/00087). Additional support was provided by grants from ADVANCE (CAT) with the support of ACCIÓ (Catalonia Trade & Investment; Generalitat de Catalunya).
DS RISalud
RD Apr 19, 2025