RT Journal Article
T1 Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
A1 Ariza-Jimenez, Ana-Belen
A1 Leiva Gea, Isabel
A1 Martinez-Aedo Ollero, Maria Jose
A1 Lopez-Siguero, Juan Pedro
K1 growth hormone treatment
K1 growth hormone deficiency
K1 idiopathic short stature
K1 final height
K1 Final height
K1 Gh therapy
K1 Children
K1 Diagnosis
K1 Childhood
K1 Velocity
K1 Gain
AB Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects. Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were -1.52 SD, -1.31 SD, and -2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD. Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups.
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/24524
UL https://hdl.handle.net/10668/24524
LA en
DS RISalud
RD Apr 7, 2025