%0 Journal Article
%A Ariza-Jimenez, Ana-Belen
%A Leiva Gea, Isabel
%A Martinez-Aedo Ollero, Maria Jose
%A Lopez-Siguero, Juan Pedro
%T Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
%D 2021
%U https://hdl.handle.net/10668/24524
%X Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects. Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were -1.52 SD, -1.31 SD, and -2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD. Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups.
%K growth hormone treatment
%K growth hormone deficiency
%K idiopathic short stature
%K final height
%K Final height
%K Gh therapy
%K Children
%K Diagnosis
%K Childhood
%K Velocity
%K Gain
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