RT Journal Article T1 Males and females with first episode psychosis present distinct profiles of social cognition and metacognition. A1 Ferrer-Quintero, M A1 Fernandez, D A1 Lopez-Carrilero, R A1 Birules, I A1 Barajas, A A1 Lorente-Rovira, E A1 Luengo, A A1 Diaz-Cutraro, L A1 Verdaguer, M A1 Garcia-Mieres, H A1 Gutierrez-Zotes, A A1 Grasa, E A1 Pousa, E A1 Huerta-Ramos, E A1 Pelaez, T A1 Barrigon, M L A1 Gomez-Benito, J A1 Gonzalez-Higueras, F A1 Ruiz-Delgado, I A1 Cid, J A1 Moritz, S A1 Sevilla-Llewellyn-Jones, J A1 Ochoa, S K1 Metacognition K1 Profiles K1 Psychosis K1 Schizophrenia K1 Sex differences K1 Social cognition K1 Área de Gestión Sanitaria Sur de Granada AB Deficits in social cognition and metacognition impact the course of psychosis. Sex differences in social cognition and metacognition could explain heterogeneity in psychosis. 174 (58 females) patients with first-episode psychosis completed a clinical, neuropsychological, social cognitive, and metacognitive assessment. Subsequent latent profile analysis split by sex yielded two clusters common to both sexes (a Homogeneous group, 53% and 79.3%, and an Indecisive group, 18.3% and 8.6% of males and females, respectively), a specific male profile characterized by presenting jumping to conclusions (28.7%) and a specific female profile characterized by cognitive biases (12.1%). Males and females in the homogeneous profile seem to have a more benign course of illness. Males with jumping to conclusions had more clinical symptoms and more neuropsychological deficits. Females with cognitive biases were younger and had lower self-esteem. These results suggest that males and females may benefit from specific targeted treatment and highlights the need to consider sex when planning interventions. PB Springer YR 2022 FD 2022-07-08 LK http://hdl.handle.net/10668/19997 UL http://hdl.handle.net/10668/19997 LA en NO Ferrer-Quintero M, Fernández D, López-Carrilero R, Birulés I, Barajas A, Lorente-Rovira E, et al. Males and females with first episode psychosis present distinct profiles of social cognition and metacognition. Eur Arch Psychiatry Clin Neurosci. 2022 Oct;272(7):1169-1181 DS RISalud RD May 10, 2025