RT Journal Article T1 A NK Cell Odyssey: From Bench to Therapeutics Against Hematological Malignancies. A1 Ramos-Mejia, Veronica A1 Arellano-Galindo, Jose A1 Mejía-Arangure, Juan Manuel A1 Cruz-Munoz, Mario Ernesto K1 NK cell K1 cancer K1 cell signaling K1 hematological malignancies K1 immuno-therapy AB In 1975 two independent groups noticed the presence of immune cells with a unique ability to recognize and eliminate transformed hematopoietic cells without any prior sensitization or expansion of specific clones. Since then, NK cells have been the axis of thousands of studies that have resulted until June 2021, in more than 70 000 publications indexed in PubMed. As result of this work, which include approaches in vitro, in vivo, and in natura, it has been possible to appreciate the role played by the NK cells, not only as effectors against specific pathogens, but also as regulators of the immune response. Recent advances have revealed previous unidentified attributes of NK cells including the ability to adapt to new conditions under the context of chronic infections, or their ability to develop some memory-like characteristics. In this review, we will discuss significant findings that have rule our understanding of the NK cell biology, the developing of these findings into new concepts in immunology, and how these conceptual platforms are being used in the design of strategies for cancer immunotherapy. YR 2022 FD 2022-04-14 LK http://hdl.handle.net/10668/20578 UL http://hdl.handle.net/10668/20578 LA en DS RISalud RD Apr 20, 2025