RT Journal Article
T1 Topical olive oil is not inferior to hyperoxygenated fatty AIDS to prevent pressure ulcers in high-risk immobilised patients in home care. Results of a multicentre randomised triple-blind controlled non-inferiority trial.
A1 Lupiáñez-Pérez, Inmaculada
A1 Uttumchandani, Shakira Kaknani
A1 Morilla-Herrera, Juan Carlos
A1 Martín-Santos, Francisco Javier
A1 Fernández-Gallego, Magdalena Cuevas
A1 Navarro-Moya, Francisco Javier
A1 Lupiáñez-Pérez, Yolanda
A1 Contreras-Fernández, Eugenio
A1 Morales-Asencio, José Miguel
K1 Úlcera por presión
K1 Atención primaria de salud
K1 Aceites vegetales
K1 Ácidos grasos
K1 Humanos
K1 España
K1 Servicios de atención de salud a domicilio
AB UNLABELLEDPressure ulcers represent a major current health problem and produce an important economic impact on the healthcare system. Most of studies to prevent pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids and to date, no studies have specifically examined the use of olive oil-based substances.METHODS AND DESIGNMain objective: To assess the effectiveness of the use of olive oil, comparing it with hyperoxygenated fatty acids, for immobilised home-care patients at risk of suffering pressure ulcers. Design: Non-inferiority, triple-blind, parallel, multicentre, randomised clinical trial. Scope: Population attending Primary Healthcare Centres in Andalusia (Spain). Sample: 831 immobilised patients at risk of suffering pressure ulcers.RESULTSThe follow-up period was 16 weeks. Groups were similar after randomization. In the per protocol analysis, none of the body areas evaluated presented risk differences for pressure ulcers incidence that exceeded the 10% delta value established. Sacrum: Olive Oil 8 (2.55%) vs HOFA 8 (3.08%), ARR 0.53 (-2.2 to 3.26) Right heel: Olive Oil 4 (1.27%) vs HOFA 5 (1.92)%, ARR0.65 (-1.43 to 2.73). Left heel: Olive Oil 3 (0.96%) vs HOFA 3 (1.15%), ARR0.2 (-1.49 to 1.88). Right trochanter: Olive Oil 0 (0%) vs HOFA 4 (1.54%), ARR1.54 (0.04 to 3.03). Left trochanter: Olive Oil 1 (0.32%) vs HOFA 1 (0.38%), ARR0.07 (-0.91 to 1.04). In the intention to treat analysis the lower limit of the established confidence interval was never exceeded.DISCUSSIONThe results obtained confirmed that the use of topical extra-virgin olive oil to prevent PU in the home environment, for immobilised patients at high risk, is not inferior to the use of HOFA. Further studies are needed to investigate the mechanism by which olive oil achieves this outcome.TRIAL REGISTRATIONClinicaltrials.gov NCT01595347.
PB Public Library of Science
YR 2015
FD 2015-04-17
LK http://hdl.handle.net/10668/2266
UL http://hdl.handle.net/10668/2266
LA en
NO Lupiáñez-Pérez I, Uttumchandani SK, Morilla-Herrera JC, Martín-Santos FJ, Fernández-Gallego MC, Navarro-Moya FJ, et al. Topical olive oil is not inferior to hyperoxygenated fatty AIDS to prevent pressure ulcers in high-risk immobilised patients in home care. Results of a multicentre randomised triple-blind controlled non-inferiority trial. PLoS ONE. 2015; 10(4):e0122238
NO Journal Article;
DS RISalud
RD Apr 11, 2025