%0 Journal Article
%A Quintela-Fandino, Miguel
%A Soberon, Nora
%A Lluch, Ana
%A Manso, Luis
%A Calvo, Isabel
%A Cortes, Javier
%A Moreno-Antón, Fernando
%A Gil-Gil, Miguel
%A Martinez-Jánez, Noelia
%A Gonzalez-Martin, Antonio
%A Adrover, Encarna
%A de Andres, Raquel
%A Viñas, Gemma
%A Llombart-Cussac, Antonio
%A Alba, Emilio
%A Mouron, Silvana
%A Guerra, Juan
%A Bermejo, Begoña
%A Zamora, Esther
%A García-Saenz, Jose Angel
%A Simon, Sonia Pernas
%A Carrasco, Eva
%A Escudero, María José
%A Campo, Ruth
%A Colomer, Ramón
%A Blasco, Maria A
%T Critically short telomeres and toxicity of chemotherapy in early breast cancer.
%D 2017
%U https://hdl.handle.net/10668/25129
%X Cumulative toxicity from weekly paclitaxel (myalgia, peripheral neuropathy, fatigue) compromises long-term administration. Preclinical data suggest that the burden of critically short telomeres ( 21.9% CSTs) had 2-fold higher number of neuropathy (P = 0.04) or fatigue (P = 0.019) episodes and >3-fold higher number of myalgia episodes (P = 0.005). The average telomere length was unrelated to the incidence of side effects.The percentage of CSTs, but not the average telomere size, is associated with weekly paclitaxel-derived toxicity.
%K breast cancer
%K critically short telomeres
%K telomere length
%K toxicity
%K weekly paclitaxel
%~