RT Journal Article T1 Advances and highlights in T and B cell responses to drug antigens. A1 Fernandez-Santamaria, Ruben A1 Ariza, Adriana A1 Fernandez, Tahia D A1 Cespedes, Jose A A1 Labella, Marina A1 Mayorga, Cristobalina A1 Torres, Maria J K1 B cell K1 T cell K1 Basic immunology K1 Drug allergy AB The immunological mechanisms involved in drug hypersensitivity reactions (DHRs) are complex, and despite important advances, multiple aspects remain poorly understood. These not fully known aspects are mainly related to the factors that drive towards either a tolerant or a hypersensitivity response and specifically regarding the role of B and T cells. In this review, we focus on recent findings on this knowledge area within the last 2 years. We highlight new evidences of covalent and non-covalent interactions of drug antigen with proteins, as well as the very first characterization of naturally processed flucloxacillin-haptenated human leukocyte antigen (HLA) ligands. Moreover, we have analysed new insights into the identification of risk factors associated with the development of DHRs, such as the role of oxidative metabolism of drugs in the activation of the immune system and the discovery of new associations between DHRs and HLA variants. Finally, evidence of IgG-mediated anaphylaxis in humans and the involvement of specific subpopulations of effector cells associated with different clinical entities are also topics explored in this review. All these recent findings are relevant for the underlying pathology mechanisms and advance the field towards a more precise diagnosis, management and treatment approach for DHRs. PB Wiley YR 2021 FD 2021-09-15 LK http://hdl.handle.net/10668/19891 UL http://hdl.handle.net/10668/19891 LA en NO Fernandez-Santamaria R, Ariza A, Fernandez TD, Cespedes JA, Labella M, Mayorga C, et al. Advances and highlights in T and B cell responses to drug antigens. Allergy. 2022 Apr;77(4):1129-1138 DS RISalud RD Apr 4, 2025