RT Journal Article
T1 COVID-19 Course in Allergic Asthma Patients: A Spanish Cohort Analysis.
A1 Habernau Mena, Alicia
A1 García-Moguel, Ismael
A1 Vazquez de la Torre Gaspar, María
A1 Mugica, Victoria
A1 Alvarado Izquierdo, Maria Isabel
A1 Jimenez Blanco, Maria Aranzazu
A1 Gandolfo-Cano, Mar
A1 Jiménez Lara, Mar
A1 Gonzalez Moreno, Ana
A1 Saura Foix, Pilar
A1 Navarro-Pulido, Ana
A1 Martin-Arriscado Arroba, Cristina
A1 Delgado Romero, Julio
A1 Dominguez-Ortega, Javier
A1 Asthma Committee of SOCIEDAD ESPAÑOLA DE ALERGOLOGÍA E INMUNOLOGÍA CLÍNICA (SEAIC), 
K1 COVID-19
K1 SARS-CoV-2
K1 allergic asthma
K1 asthma phenotype
K1 eosinophils
AB The acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a high impact on patients with chronic diseases. In the literature, there are different perspectives on asthma as comorbidity or risk factor on COVID-19 severity. The aim of this retrospective study across 13 allergy departments in Spain was to determine the severity of COVID-19 in asthmatic adults followed in allergy departments and its relationship with atopy, clinical and demographic characteristics, phenotypes and laboratory data. In addition, lung function test and asthma control test (ACT) before and after COVID-19 were analyzed. Data was obtained from electronic medical records from March 2020 to April 2021. Two hundred one asthmatic patients were diagnosed with COVID-19 infection by validated detection test. About 30% of the patients were admitted for bilateral pneumonia. Advanced age, elevated D-dimer, lower numbers of lymphocytes and eosinophils, heart diseases and hypertension were associated with severe COVID-19. Allergic and mixed allergic/eosinophilic phenotype and their biomarkers (total IgE, aeroallergens sensitizations, allergic rhinitis, and blood eosinophilia) were related to fewer hospital admissions. Poor control and lower forced expiratory volume in the first second (FEV1) were related to worse prognosis of COVID-19. Asthmatic patients with allergic and eosinophilic phenotype have a better evolution of COVID-19 and lower risk of admissions. Older patients, cardiovascular comorbidities, AERD and eosinopenia are related to severity COVID-19.
SN 1178-6965
YR 2022
FD 2022-02-22
LK http://hdl.handle.net/10668/20468
UL http://hdl.handle.net/10668/20468
LA en
DS RISalud
RD Apr 9, 2025