TY - GEN AU - Barrios, Vicente AU - Chowen, Julie A. AU - Martin-Rivada, Alvaro AU - Guerra-Cantera, Santiago AU - Pozo, Jesus AU - Yakar, Shoshana AU - Rosenfeld, Ron G. AU - Perez-Jurado, Luis A. AU - Suarez, Juan AU - Argente, Jesus PY - 2021 DO - 10.3390/cells10123576 UR - https://hdl.handle.net/10668/28358 T2 - Cells AB - The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and... LA - en PB - Mdpi KW - growth hormone axis KW - IGF1 KW - IGF2 KW - IGFBPs KW - PAPP-A KW - PAPP-A2 KW - STC1 KW - STC2 KW - Factor-binding protein-3 KW - Growth-factor-i KW - High-fat diet KW - A papp-a KW - Proteolytic activity KW - Negative regulator KW - Postnatal-growth KW - Glucose disposal KW - Bone loss KW - Insulin TI - Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease TY - review VL - 10 ER -