RT Generic
T1 Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease
A1 Barrios, Vicente
A1 Chowen, Julie A.
A1 Martin-Rivada, Alvaro
A1 Guerra-Cantera, Santiago
A1 Pozo, Jesus
A1 Yakar, Shoshana
A1 Rosenfeld, Ron G.
A1 Perez-Jurado, Luis A.
A1 Suarez, Juan
A1 Argente, Jesus
K1 growth hormone axis
K1 IGF1
K1 IGF2
K1 IGFBPs
K1 PAPP-A
K1 PAPP-A2
K1 STC1
K1 STC2
K1 Factor-binding protein-3
K1 Growth-factor-i
K1 High-fat diet
K1 A papp-a
K1 Proteolytic activity
K1 Negative regulator
K1 Postnatal-growth
K1 Glucose disposal
K1 Bone loss
K1 Insulin
AB The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-specific manner that requires precise control that is not completely understood. Some of the most recent advances in understanding the implications of this axis in human growth are derived from the identifications of new mutations in the gene encoding the pregnancy-associated plasma protein PAPP-A2 protease that liberates IGFs from their carrier proteins in a selective manner to allow binding to the IGF receptor 1. The identification of three nonrelated families with mutations in the PAPP-A2 gene has shed light on how this protease affects human physiology. This review summarizes our understanding of the implications of PAPP-A2 in growth physiology, obtained from studies in genetically modified animal models and the PAPP-A2 deficient patients known to date.
PB Mdpi
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/28358
UL https://hdl.handle.net/10668/28358
LA en
DS RISalud
RD Apr 17, 2025