RT Journal Article
T1 Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.
A1 López-Mejías, Raquel
A1 Genre, Fernanda
A1 Remuzgo-Martínez, Sara
A1 González-Juanatey, Carlos
A1 Robustillo-Villarino, Montserrat
A1 Llorca, Javier
A1 Corrales, Alfonso
A1 Vicente, Esther
A1 Miranda-Filloy, José A
A1 Magro, César
A1 Tejera-Segura, Beatriz
A1 Ramírez Huaranga, Marco A
A1 Pina, Trinitario
A1 Blanco, Ricardo
A1 Alegre-Sancho, Juan J
A1 Raya, Enrique
A1 Mijares, Verónica
A1 Ubilla, Begoña
A1 Mínguez Sánchez, María D
A1 Gómez-Vaquero, Carmen
A1 Balsa, Alejandro
A1 Pascual-Salcedo, Dora
A1 López-Longo, Francisco J
A1 Carreira, Patricia
A1 González-Álvaro, Isidoro
A1 Rodríguez-Rodríguez, Luis
A1 Fernández-Gutiérrez, Benjamín
A1 Ferraz-Amaro, Iván
A1 Castañeda, Santos
A1 Martín, Javier
A1 González-Gay, Miguel A
K1 Artritis reumatoide
K1 Aterosclerosis
K1 Proteína c-reactiva
K1 Grosor intima-media carotídeo
K1 Genotipo
K1 Humanos
K1 Polimorfismo genético
AB Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.
PB Nature Publishing Group
YR 2016
FD 2016-08-18
LK http://hdl.handle.net/10668/2474
UL http://hdl.handle.net/10668/2474
LA en
NO López-Mejías R, Genre F, Remuzgo-Martínez S, González-Juanatey C, Robustillo-Villarino M, Llorca J, et al. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis. Sci Rep. 2016; 6:31979
NO Journal Article;
DS RISalud
RD Apr 8, 2025