RT Journal Article
T1 Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition.
A1 Caini, Saverio
A1 Masala, Giovanna
A1 Saieva, Calogero
A1 Kvaskoff, Marina
A1 Savoye, Isabelle
A1 Sacerdote, Carlotta
A1 Hemmingsson, Oskar
A1 Hammer Bech, Bodil
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Petersen, Kristina E N
A1 Mancini, Francesca Romana
A1 Boutron-Ruault, Marie-Christine
A1 Cervenka, Iris
A1 Kaaks, Rudolf
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Floegel, Anna
A1 Trichopoulou, Antonia
A1 Valanou, Elisavet
A1 Kritikou, Maria
A1 Tagliabue, Giovanna
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Veierød, Marit B
A1 Ghiasvand, Reza
A1 Lukic, Marko
A1 Quirós, José Ramón
A1 Chirlaque, Maria-Dolores
A1 Ardanaz, Eva
A1 Salamanca Fernández, Elena
A1 Larrañaga, Nerea
A1 Zamora-Ros, Raul
A1 Maria Nilsson, Lena
A1 Ljuslinder, Ingrid
A1 Jirström, Karin
A1 Sonestedt, Emily
A1 Key, Timothy J
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Gunter, Marc
A1 Huybrechts, Inge
A1 Murphy, Neil
A1 Tsilidis, Konstantinos K
A1 Weiderpass, Elisabete
A1 Palli, Domenico
K1 coffee
K1 cohort study
K1 melanoma
K1 risk
K1 tea
AB In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25-70 years from ten European countries in 1992-2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow-up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non-consumers 0.31, 95% CI 0.14-0.69) but not among women (HR 0.96, 95% CI 0.62-1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.
YR 2017
FD 2017-03-09
LK http://hdl.handle.net/10668/10883
UL http://hdl.handle.net/10668/10883
LA en
DS RISalud
RD Apr 19, 2025