RT Journal Article
T1 Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication.
A1 Alameda, Luis
A1 Levier, Axel
A1 Gholam-Rezaee, Mehdi
A1 Golay, Philippe
A1 Vandenberghe, Frederik
A1 Delacretaz, Aurélie
A1 Baumann, Philipp
A1 Glatard, Anaïs
A1 Dubath, Céline
A1 Herane-Vives, Andres
A1 Rodriguez, Victoria
A1 Solida, Alessandra
A1 Do, Kim Q
A1 Eap, Chin B
A1 Conus, Philippe
AB It has been suggested that exposure to Childhood Trauma [CT] may play a role in the risk of obesity in Early Psychosis [EP] patients; however, whether this is independently of age at exposure to CT and the medication profile has yet to be investigated. 113 EP-patients aged 18-35 were recruited from the Treatment and Early Intervention in Psychosis Program [TIPP-Lausanne]. Body Mass Index [BMI], Weight Gain [WG] and Waist Circumference [WC] were measured prospectively at baseline and after 1, 2, 3, 6 and 12 months of weight gain inducing psychotropic treatment. Patients were classified as Early-Trauma and Late-Trauma if the exposure had occurred before age 12 or between ages 12 and 16 respectively. Generalized Linear Mixed-Models were adjusted for age, sex, socioeconomic status, baseline BMI, medication and for diagnosis of depression. Late-Trauma patients, when compared to Non-Trauma patients showed greater WCs during the follow-up [p = 0.013]. No differences were found in any of the other follow-up measures. Exposition to CT during adolescence in EP-patients treated with psychotropic medication is associated with greater WC during the early phase of the disease. Further investigation exploring mechanisms underlying the interactions between peripubertal stress, corticoids responsiveness and a subsequent increase of abdominal adiposity is warranted.
YR 2020
FD 2020-12-03
LK http://hdl.handle.net/10668/16725
UL http://hdl.handle.net/10668/16725
LA en
DS RISalud
RD Apr 10, 2025