%0 Journal Article
%A Alameda, Luis
%A Levier, Axel
%A Gholam-Rezaee, Mehdi
%A Golay, Philippe
%A Vandenberghe, Frederik
%A Delacretaz, Aurélie
%A Baumann, Philipp
%A Glatard, Anaïs
%A Dubath, Céline
%A Herane-Vives, Andres
%A Rodriguez, Victoria
%A Solida, Alessandra
%A Do, Kim Q
%A Eap, Chin B
%A Conus, Philippe
%T Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication.
%D 2020
%U http://hdl.handle.net/10668/16725
%X It has been suggested that exposure to Childhood Trauma [CT] may play a role in the risk of obesity in Early Psychosis [EP] patients; however, whether this is independently of age at exposure to CT and the medication profile has yet to be investigated. 113 EP-patients aged 18-35 were recruited from the Treatment and Early Intervention in Psychosis Program [TIPP-Lausanne]. Body Mass Index [BMI], Weight Gain [WG] and Waist Circumference [WC] were measured prospectively at baseline and after 1, 2, 3, 6 and 12 months of weight gain inducing psychotropic treatment. Patients were classified as Early-Trauma and Late-Trauma if the exposure had occurred before age 12 or between ages 12 and 16 respectively. Generalized Linear Mixed-Models were adjusted for age, sex, socioeconomic status, baseline BMI, medication and for diagnosis of depression. Late-Trauma patients, when compared to Non-Trauma patients showed greater WCs during the follow-up [p = 0.013]. No differences were found in any of the other follow-up measures. Exposition to CT during adolescence in EP-patients treated with psychotropic medication is associated with greater WC during the early phase of the disease. Further investigation exploring mechanisms underlying the interactions between peripubertal stress, corticoids responsiveness and a subsequent increase of abdominal adiposity is warranted.
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