RT Journal Article T1 Prepubertal Children With Metabolically Healthy Obesity or Overweight Are More Active Than Their Metabolically Unhealthy Peers Irrespective of Weight Status: GENOBOX Study. A1 Llorente-Cantarero, Francisco Jesus A1 Leis, Rosaura A1 Ruperez, Azahara I A1 Anguita-Ruiz, Augusto A1 Vazquez-Cobela, Rocio A1 Flores-Rojas, Katherine A1 Gonzalez-Gil, Esther M A1 Aguilera, Concepcion M A1 Moreno, Luis A A1 Gil-Campos, Mercedes A1 Bueno, Gloria K1 Body composition K1 Body mass index K1 Childhood K1 Health K1 Metabolic syndrome K1 Metabolism K1 Physical activity AB The association of a metabolically healthy status with the practice of physical activity (PA) remains unclear. Sedentarism and low PA have been linked to increased cardiometabolic risk. The aim of this study was to evaluate the PA levels in metabolically healthy (MH) or unhealthy (MU) prepubertal children with or without overweight/obesity. A total 275 children (144 boys) with 9 ± 2 years old were selected for the GENOBOX study. PA times and intensities were evaluated by accelerometry, and anthropometry, blood pressure, and blood biochemical markers were analyzed. Children were considered to have normal weight or obesity, and further classified as MH or MU upon fulfillment of the considered metabolic criteria. Classification resulted in 119 MH children (21% with overweight/obesity, referred to as MHO) and 156 MU children (47% with overweight/obesity, referred to as MUO). Regarding metabolic profile, MHO showed lower blood pressure levels, both systolic and diastolic and biochemical markers levels, such as glucose, Homeostatic Model Assessment of Insulin Resistance, triglycerides and higher HDL-c levels than MUO (P Prepubertal MHO children are less sedentary, more active, and have better metabolic profiles than their MUO peers. However, all children, especially girls, should increase their PA engagement, both in terms of time and intensity because PA appears to be beneficial for metabolic health status itself. PB Frontiers Research Foundation SN 2296-861X YR 2022 FD 2022-02-22 LK http://hdl.handle.net/10668/20658 UL http://hdl.handle.net/10668/20658 LA en NO Llorente-Cantarero FJ, Leis R, Rupérez AI, Anguita-Ruiz A, Vázquez-Cobela R, Flores-Rojas K, et al. Prepubertal Children With Metabolically Healthy Obesity or Overweight Are More Active Than Their Metabolically Unhealthy Peers Irrespective of Weight Status: GENOBOX Study. Front Nutr. 2022 Apr 12;9:821548 DS RISalud RD Apr 4, 2025