RT Journal Article
T1 Night shift work and chronic lymphocytic leukemia in the MCC-Spain case-control study.
A1 Costas, Laura
A1 Benavente, Yolanda
A1 Olmedo-Requena, Rocio
A1 Casabonne, Delphine
A1 Robles, Claudia
A1 Gonzalez-Barca, Eva-Maria
A1 de la Banda, Esmeralda
A1 Alonso, Esther
A1 Aymerich, Marta
A1 Tardon, Adonina
A1 Marcos-Gragera, Rafael
A1 Gimeno-Vazquez, Eva
A1 Gomez-Acebo, Ines
A1 Papantoniou, Kyriaki
A1 Castaño-Vinyals, Gemma
A1 Aragones, Nuria
A1 Pollan, Marina
A1 Kogevinas, Manolis
A1 de Sanjose, Silvia
K1 case-control study
K1 chronic lymphocytic leukemia
K1 night shift work
AB Chronic lymphocytic leukemia (CLL) has few known modifiable risk factors. Recently, circadian disruption has been proposed as a potential contributor to lymphoid neoplasms' etiology. Serum melatonin levels have been found to be significantly lower in CLL subjects compared with healthy controls, and also, CLL prognosis has been related to alterations in the circadian molecular signaling. We performed the first investigation of an association between night shift work and CLL in 321 incident CLL cases and 1728 population-based controls in five areas of Spain. Participants were interviewed face-to-face by trained interviewers to collect information on sociodemographic factors, familial, medical and occupational history, including work shifts and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate odds ratios (OR) and 95% confidence intervals (CI). Seventy-nine cases (25%) and 339 controls (20%) had performed night work. Overall, working in night shifts was not associated with CLL (OR = 1.06; 95% CI = 0.78-1.45, compared with day work). However, long-term night shift (>20 years) was positively associated with CLL (OR(tertile 3 vs . day-work)  = 1.77; 95% = 1.14-2.74), although no linear trend was observed (P trend = 0.18). This association was observed among those with rotating (OR(tertile 3 vs . day-work)  = 2.29; 95% CI = 1.33-3.92; P trend = 0.07), but not permanent night shifts (OR(tertile 3 vs . day-work) = 1.16; 95% CI = 0.60-2.25; P trend = 0.86). The association between CLL and long-term rotating night shift warrants further investigation.
PB John Wiley & Sons, Inc.
YR 2016
FD 2016-07-14
LK http://hdl.handle.net/10668/10267
UL http://hdl.handle.net/10668/10267
LA en
NO ostas L, Benavente Y, Olmedo-Requena R, Casabonne D, Robles C, Gonzalez-Barca EM, et al. Night shift work and chronic lymphocytic leukemia in the MCC-Spain case-control study. Int J Cancer. 2016 Nov 1;139(9):1994-2000.
DS RISalud
RD Apr 16, 2025