RT Journal Article
T1 Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer
A1 Sánchez-Alcoholado, Lidia
A1 Ordóñez, Rafael
A1 Otero, Ana
A1 Plaza-Andrade, Isaac
A1 Laborda-Illanes, Aurora
A1 Medina, José Antonio
A1 Ramos-Molina, Bruno
A1 Gómez-Millán, Jaime
A1 Queipo-Ortuño, María Isabel
K1 Colorectal cancer
K1 Gut microbiota
K1 Obesity
K1 Inflammation
K1 Gut permeability
K1 TMAO
K1 Neoplasias colorrectales
K1 Microbioma gastrointestinal
K1 Obesidad
K1 Inflamación
AB Obesity is considered an important factor that increases the risk of colorectal cancer (CRC). So far, the association of gut microbiota with both obesity and cancer has been described independently. Nevertheless, a specific obesity-related microbial profile linked to CRC development has not been identified. The aim of this study was to determine the gut microbiota composition in fecal samples from CRC patients with (OB-CRC) and without obesity (L-CRC) compared to the microbiota profile present in non-obese healthy controls (L-HC), in order to unravel the possible relationship between gut microbiota and microbial-derived metabolite trimethylamine N-oxide (TMAO), the inflammatory status, and the intestinal permeability in the context of obesity-associated CRC. The presence of obesity does not induce significant changes in the diversity and richness of intestinal bacteria of CRC patients. Nevertheless, OB-CRC patients display a specific gut microbiota profile characterized by a reduction in butyrate-producing bacteria and an overabundance of opportunistic pathogens, which in turn could be responsible, at least in part, for the higher levels of proinflammatory cytokine IL-1β, the deleterious bacterial metabolite TMAO, and gut permeability found in these patients. These results suggest a possible role of obesity-related gut microbiota in the development of CRC, which could give new clues for the design of new diagnostic tools for CRC prevention.
PB MDPI
SN 1661-6596
YR 2020
FD 2020-09-16
LK http://hdl.handle.net/10668/4063
UL http://hdl.handle.net/10668/4063
LA en
NO Sánchez-Alcoholado L, Ordóñez R, Otero A, Plaza-Andrade I, Laborda-Illanes A, Medina JA, et al. Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer. Int J Mol Sci. 2020 Sep 16;21(18):6782
DS RISalud
RD Apr 8, 2025