RT Journal Article
T1 Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis
A1 Arias de la Rosa, Iván
A1 Font, Pilar
A1 Escudero-Contreras, Alejandro
A1 López-Montilla, María Dolores
A1 Pérez-Sánchez, Carlos
A1 Ábalos-Aguilera, María Carmen
A1 Ladehesa-Pineda, Lourdes
A1 Ibáñez-Costa, Alejandro
A1 Torres-Granados, Carmen
A1 Jimenez-Gomez, Yolanda
A1 Patiño-Trives, Alejandra
A1 Luque-Tévar, María
A1 Castro-Villegas, María Carmen
A1 Calvo-Gutiérrez, Jerusalem
A1 Ortega-Castro, Rafaela
A1 López-Pedrera, Chary
A1 Collantes-Estévez, Eduardo
A1 Barbarroja, Nuria
K1 Axial spondyloarthritis
K1 Cardiovascular risk
K1 Complement C3
K1 Disease activity
K1 Obesity
K1 Psoriatic arthritis
K1 Rheumatoid arthritis
K1 Factores de riesgo de enfermedad cardiaca
K1 Complemento C3
K1 Obesidad
K1 Artritis psoriásica
K1 Artritis reumatoide
K1 Espondilitis anquilosante
AB Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).Methods: This is a cross-sectional study including 200 RA, 80 PsA, 150 axSpA patients and 100 healthy donors. The prevalence of cardiometabolic risk factors [obesity, insulin resistance, type 2 diabetes mellitus, hyperlipidemia, apolipoprotein B/apolipoprotein A (apoB/apoA) and atherogenic risks and hypertension] was analyzed. Serum complement C3 levels, inflammatory markers and disease activity were evaluated. Cluster analysis was performed to identify different phenotypes. Receiver operating characteristic (ROC) curve analysis to assess the accuracy of complement C3 as biomarker of insulin resistance and disease activity was carried out.Results: Levels of complement C3, significantly elevated in RA, axSpA and PsA patients, were associated with the prevalence of cardiometabolic risk factors. Hard clustering analysis identified two distinctive phenotypes of patients depending on the complement C3 levels and insulin sensitivity state. Patients from cluster 1, characterized by high levels of complement C3 displayed increased prevalence of cardiometabolic risk factors and high disease activity. ROC curve analysis showed that non-obesity related complement C3 levels allowed to identify insulin resistant patients.Conclusions: Complement C3 is associated with the concomitant increased prevalence of cardiometabolic risk factors in rheumatoid arthritis and spondyloarthritis. Thus, complement C3 should be considered a useful marker of insulin resistance and disease activity in these rheumatic disorders.
PB SAGE Publications
SN 2040-6223
YR 2020
FD 2020-10-21
LK http://hdl.handle.net/10668/3569
UL http://hdl.handle.net/10668/3569
LA en
NO Arias de la Rosa I, Font P, Escudero-Contreras A, López-Montilla MD, Pérez-Sánchez C, Ábalos-Aguilera MC, et al. Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis. Ther Adv Chronic Dis. 2020 Oct 21;11:2040622320965067
DS RISalud
RD Apr 11, 2025