%0 Journal Article
%A Llerena, Susana
%A Cabezas, Joaquín
%A Cuadrado, Antonio
%A Manuel Olmos, José
%A González, Marta
%A García, Federico
%A Cobo, Carmen
%A Crespo, Javier
%T Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done.
%D 2019
%@ 1665-2681
%U http://hdl.handle.net/10668/13999
%X Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients.
%K Genotype 3
%K Grazoprevir + Elbasvir
%K Hepatitis C virus
%K Sofosbuvir
%K Treatment failure
%~