RT Journal Article
T1 Pharmacogenetic polymorphisms affecting bisoprolol response
A1 Castaño-Amores, Celia
A1 Díaz-Villamarín, Xando
A1 Pérez-Gutiérrez, Ana María
A1 Antúnez-Rodríguez, Alba
A1 Pozo-Agundo, Ana
A1 Moreno-Escobar, Eduardo
A1 Sánchez-Ramos, Jesús Gabriel
A1 Martínez-González, Luis Javier
A1 Dávila-Fajardo, Cristina Lucía
K1 Bisoprolol
K1 Pharmacogenetic
K1 β-blockers
K1 Cardiovascular diseases
K1 Personalized medicine
K1 Farmacogenética
K1 Anticuerpos bloqueadores
K1 Enfermedades cardiovasculares
K1 Medicina de precisión
AB β-blockers are commonly prescribed to treat multiple cardiovascular (CV) diseases, but, frequently, adverse drug reactions and intolerance limit their use in clinical practice. Interindividual variability in response to β-blockers may be explained by genetic differences. In fact, pharmacogenetic interactions for some of these drugs have been widely studied, such as metoprolol. But studies that explore genetic variants affecting bisoprolol response are inconclusive, limited or confusing because of mixed results with other β-Blockers, different genetic polymorphisms observed, endpoint studied etc. Because of this, we performed a systematic review in order to find relevant genetic variants affecting bisoprolol response. We have found genetic polymorphism in several genes, but most of the studies focused in ADRB variants. The ADRB1 Arg389Gly (rs1801253) was the most studied genetic polymorphism and it seems to influence the response to bisoprolol, although studies are inconclusive. Even, we performed a meta-analysis about its influence on systolic/diastolic blood pressure in patients treated with bisoprolol, but this did not show statistically significant results. In conclusion, many genetic polymorphisms have been assessed about their influence on patients´ response to bisoprolol and the ADRB1 Arg389Gly (rs1801253) seems the most relevant genetic polymorphism in this regard but results have not been confirmed with a meta-analysis. Our results support the need of further studies about the impact of genetic variants on bisoprolol response, considering different genetic polymorphisms and conducting single and multiple SNPs analysis, including other clinical parameters related to bisoprolol response in a multivariate study.
PB Elsevier
SN 0753-3322
YR 2021
FD 2021-08-27
LK http://hdl.handle.net/10668/4062
UL http://hdl.handle.net/10668/4062
LA en
NO Castaño-Amores C, Díaz-Villamarín X, Pérez-Gutiérrez AM, Antúnez-Rodríguez A, Pozo-Agundo A, Moreno-Escobar E, et al. Pharmacogenetic polymorphisms affecting bisoprolol response. Biomed Pharmacother. 2021 Oct;142:112069
DS RISalud
RD Apr 5, 2025