RT Journal Article
T1 H. pylori eradication with antibiotic treatment causes changes in glucose homeostasis related to modifications in the gut microbiota.
A1 Martín-Núñez, Gracia Mª
A1 Cornejo-Pareja, Isabel
A1 Coin-Aragüez, Leticia
A1 Roca-Rodríguez, Mª Del Mar
A1 Muñoz-Garach, Araceli
A1 Clemente-Postigo, Mercedes
A1 Cardona, Fernando
A1 Moreno-Indias, Isabel
A1 Tinahones, Francisco J
AB H. pylori infection and eradication cause perturbations of the gut microbiome. The gut microbiota has been identified as a potential contributor to metabolic diseases. We evaluate whether these alterations in intestinal microbiota composition produced by H. pylori infection and its posterior eradication with antibiotic treatment could be associated with glucose homeostasis in metabolically healthy subjects. Forty adult patients infected with H. pylori and 20 control subjects were recruited. The infected subjects were evaluated before and two months after eradication treatment (omeprazole, clarithromycin, amoxicillin). The microbiota composition in fecal samples was determined by 16S rRNA gene (V3-V4) sequencing using Illumina Miseq. Patients (pre- and post-H. pylori eradication) showed a decreased bacterial richness and diversity with respect to controls. There was an improvement in glucose homeostasis in subjects two months after H. pylori eradication treatment. Changes in the amount of Rikenellaceae, Butyricimonas, E. biforme, B. fragilis, and Megamonas were inversely associated with changes in the glucose level or related parameters (Hb1ac) in H. pylori eradication subjects. H. pylori infection and eradication with antibiotic treatment causes alteration of the human gut microbiome. The increase in SCFA-producing bacteria and glucose-removing bacteria, specifically members of Megamonas, Rikenellaceae and Butyricimonas, has been related with an improvement in glucose homeostasis after H. pylori eradication with antibiotic treatment.
YR 2019
FD 2019-03-14
LK http://hdl.handle.net/10668/13705
UL http://hdl.handle.net/10668/13705
LA en
DS RISalud
RD Apr 19, 2025