RT Journal Article
T1 Primary cerebral malignant melanoma in insular region with extracranial metastasis: case report and review literature.
A1 Troya-Castilla, Marta
A1 Rocha-Romero, Santiago
A1 Chocrón-González, Yamin
A1 Márquez-Rivas, Francisco Javier
K1 Bleeding
K1 Cerebral
K1 Melanoma
K1 Metastasis
K1 Primary
AB Primary brain melanomas are very infrequent and metastasis outside central nervous system very uncommon. There are some cases in the literature about primary melanoma in the temporal lobe; nevertheless, the insular location has never been described. The patient presented as left insular intraparenchymal hematoma with multiple bleedings. Complementary tests did not show any tumoral nor vascular pattern in relation with these bleedings. A complete surgical resection was performed, and the diagnosis of malignant melanoma, with BRAF mutation, was obtained after histology exam. Extension studies were negative for skin or mucous melanoma. 18F-FDG PET/CT was performed and a metastatic lymph node was found. The diagnosis was primary brain melanoma with extracerebral metastasis. Dabrafenib 150 mg/12 h was the only chemotherapy during 5 months. After that, Trametinib 2 mg/24 h was added to the treatment. Eighteen months after surgery, the patient is independent, with stable situation, and without new metastasis. Although malignant melanomas have poor prognosis, total surgical resection and new therapies are increasing the overall survival and improving quality of life. In a patient with suspected brain melanoma, in spite of having extracerebral metastasis, aggressive treatment may be considered.
YR 2016
FD 2016-09-01
LK http://hdl.handle.net/10668/10409
UL http://hdl.handle.net/10668/10409
LA en
DS RISalud
RD Apr 19, 2025