RT Journal Article
T1 Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
A1 Agudo, Antonio
A1 Cayssials, Valerie
A1 Bonet, Catalina
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Affret, Aurélie
A1 Fagherazzi, Guy
A1 Katzke, Verena
A1 Schübel, Ruth
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 La Vecchia, Carlo
A1 Palli, Domenico
A1 Grioni, Sara
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, Bas
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Skeie, Guri
A1 Nøst, Theresa H
A1 Lasheras, Cristina
A1 Rodríguez-Barranco, Miguel
A1 Amiano, Pilar
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Ohlsson, Bodil
A1 Dias, Joana A
A1 Nilsson, Lena M
A1 Myte, Robin
A1 Khaw, Kay-Tee
A1 Perez-Cornago, Aurora
A1 Gunter, Marc
A1 Huybrechts, Inge
A1 Cross, Amanda J
A1 Tsilidis, Kostas
A1 Riboli, Elio
A1 Jakszyn, Paula
AB Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders. The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively. Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/12328
UL http://hdl.handle.net/10668/12328
LA en
DS RISalud
RD Apr 14, 2025