RT Journal Article
T1 Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
A1 Hughes, David J
A1 Duarte-Salles, Talita
A1 Hybsier, Sandra
A1 Trichopoulou, Antonia
A1 Stepien, Magdalena
A1 Aleksandrova, Krasimira
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Affret, Aurélie
A1 Fagherazzi, Guy
A1 Boutron-Ruault, Marie-Christine
A1 Katzke, Verena
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Bamia, Christina
A1 Lagiou, Pagona
A1 Peppa, Eleni
A1 Palli, Domenico
A1 Krogh, Vittorio
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Bueno-de-Mesquita, Hendrik Bastiaan
A1 Peeters, Petra H
A1 Engeset, Dagrun
A1 Weiderpass, Elisabete
A1 Lasheras, Cristina
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Navarro, Carmen
A1 Ardanaz, Eva
A1 Dorronsoro, Miren
A1 Hemmingsson, Oskar
A1 Wareham, Nicholas J
A1 Khaw, Kay-Tee
A1 Bradbury, Kathryn E
A1 Cross, Amanda J
A1 Gunter, Marc
A1 Riboli, Elio
A1 Romieu, Isabelle
A1 Schomburg, Lutz
A1 Jenab, Mazda
K1 hepatobiliary cancer
K1 hepatocellular carcinoma
K1 liver cancer
K1 prospective cohort
K1 selenium
K1 selenium status
K1 selenoprotein P
AB Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression. HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-μg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ≤ 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63). These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
YR 2016
FD 2016-06-29
LK http://hdl.handle.net/10668/10224
UL http://hdl.handle.net/10668/10224
LA en
DS RISalud
RD Apr 9, 2025