%0 Journal Article
%A Baglietto-Vargas, David
%A Forner, Stefania
%A Cai, Lena
%A Martini, Alessandra C.
%A Trujillo-Estrada, Laura
%A Swarup, Vivek
%A Nguyen, Marie Minh Thu
%A Do Huynh, Kelly
%A Javonillo, Dominic I.
%A Tran, Kristine Minh
%A Phan, Jimmy
%A Jiang, Shan
%A Kramár, Enikö A.
%A Nuñez-Diaz, Cristina
%A Balderrama-Gutierrez, Gabriela
%A Garcia, Franklin
%A Childs, Jessica
%A Rodriguez-Ortiz, Carlos J.
%A Garcia-Leon, Juan Antonio
%A Kitazawa, Masashi
%A Shahnawaz, Mohammad
%A Matheos, Dina P.
%A Ma, Xinyi
%A Da Cunha, Celia
%A Walls, Ken C.
%A Ager, Rahasson R.
%A Soto, Claudio
%A Gutierrez, Antonia
%A Moreno-Gonzalez, Ines
%A Mortazavi, Ali
%A Tenner, Andrea J.
%A MacGregor, Grant R.
%A Wood, Marcelo
%A Green, Kim N.
%A LaFerla, Frank M.
%T Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology
%D 2021
%U http://hdl.handle.net/10668/4585
%X The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. Remarkably, changing 3 amino acids in the mouse Aβ sequence to its wild-type human counterpart leads to age-dependent impairments in cognition and synaptic plasticity, brain volumetric changes, inflammatory alterations, the appearance of Periodic Acid-Schiff (PAS) granules and changes in gene expression. In addition, when exon 14 encoding the Aβ sequence was flanked by loxP sites we show that Cre-mediated excision of exon 14 ablates hAβ expression, rescues cognition and reduces the formation of PAS granules.
%K Periodic acid-schiff
%K Exon
%K Cognition
%K Mutation
%K Gene expression
%K Alzheimer disease
%K Reacción del ácido peryódico de Schiff
%K Exones
%K Cognición
%K Mutación
%K Expresión génica
%K Enfermedad de Alzheimer
%~