RT Journal Article
T1 Palliative analgesia with topical sevoflurane in cancer-related skin ulcers: a case report.
A1 Fernández-Ginés, F Dámaso
A1 Cortiñas-Sáenz, Manuel
A1 Navajas-Gómez de Aranda, Ana
A1 Navas-Martinez, Maria Del Carmen
A1 Morales-Molina, José Antonio
A1 Sierra-García, Francisco
A1 Mateo-Carrasco, Héctor
K1 palliative care
K1 penile cancer
K1 refractory pain
K1 sevoflurane
K1 skin ulcer
K1 topical drug administration
AB A Caucasian 39-year-old male patient with a poorly-differentiated infiltrating epidermoid penile carcinoma with urethral invasion was diagnosed. The patient received concomitant adjuvant chemotherapy with radiotherapy in the palliative setting, which produced painful ulceration of tumour lesions at loco-regional level (Numerical Rate Scale, NRS=9). The patient consented for treatment with direct topical sevoflurane instillations, at initial doses of 1 mL/cm2 of ulcerated area, as per unit protocol. The local use of undiluted sevoflurane achieved a marked reduction of the pain score in both nociceptive and irruptive pains (average NRS=3 immediately post-application). This improvement was corroborated by a decline in total morphine needs, any adverse events associated with major opiates. PGI-I and CGI-I scales were used before and after treatment with topical sevoflurane to assess patient and clinician perceptions of improvement in the quality of life. The pharmacy of our hospital had the responsibility to elaborate pre-loaded syringes with sevoflurane so that the patient was instilled simply and comfortably.
SN 2047-9956
YR 2018
FD 2018-01-11
LK http://hdl.handle.net/10668/14296
UL http://hdl.handle.net/10668/14296
LA en
DS RISalud
RD Apr 12, 2025