RT Journal Article
T1 Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months
A1 Martin-Borreguero, Pilar
A1 Gómez-Fernández, Antonio Rafael
A1 De La Torre-Aguilar, Maria Jose
A1 Gil-Campos, Mercedes
A1 Flores-Rojas, Katherine
A1 Perez-Navero, Juan Luis
K1 Autism
K1 Children
K1 Neurodevelopmental regression
K1 Diagnostic measurements
K1 Autism severity
K1 Autism spectrum disorder
K1 Developmental disorders
K1 Trastorno autístico
K1 Niño
K1 Trastorno del espectro autista
AB This study examined the presence of neurodevelopmental regression and its effects on the clinical manifestations and the severity of autism spectrum disorder (ASD) in a group of children with autism compared with those without neurodevelopmental regression at the time of initial classification and subsequently. Methods and Subjects: ASD patients were classified into two subgroups, neurodevelopmental regressive (AMR) and non-regressive (ANMR), using a questionnaire based on the Autism Diagnostic Interview-Revised test. The severity of ASD and neurodevelopment were assessed with the Childhood Autism Rating Scale Test-2, Strengths and Difficulties Questionnaire, and Pervasive Developmental Disorders Behavior Inventory Parent Ratings (PDDBI) and with the Battelle Developmental Inventory tests at the beginning of the study and after 24 months of follow-up. Fifty-two patients aged 2-6 years with ASD were included. Nineteen were classified with AMR, and 33 were classified with ANMR. Results: The AMR subgroup presented greater severity of autistic symptoms and higher autism scores. Additionally, they showed lower overall neurodevelopment. The AMR subgroup at 24 months had poorer scores on the Battelle Developmental Inventory test in the following areas: Total personal/social (p < 0.03), Total Motor (p < 0.04), Expressive (p < 0.01), and Battelle Total (p < 0.04). On the PDDBI test, the AMR subgroup had scores indicating significantly more severe ASD symptoms in the variables: ritual score (p < 0.038), social approach behaviors (p < 0.048), expressive language (p < 0.002), and autism score (p < 0.003). Conclusions: ASD patients exhibited a set of different neurological phenotypes. The AMR and ANMR subgroups presented different clinical manifestations and prognoses in terms of the severity of autistic symptoms and neurodevelopment.
PB Frontiers
YR 2021
FD 2021-03-26
LK http://hdl.handle.net/10668/4233
UL http://hdl.handle.net/10668/4233
LA en
NO Martin-Borreguero P, Gómez-Fernández AR, De La Torre-Aguilar MJ, Gil-Campos M, Flores-Rojas K, Perez-Navero JL. Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months. Front Psychiatry. 2021 Mar 26;12:644324.
DS RISalud
RD Apr 17, 2025