RT Journal Article
T1 Biocompatible Dialysis Solutions Preserve Peritoneal Mesothelial Cell and Vessel Wall Integrity. A Case-Control Study on Human Biopsies.
A1 del Peso, Gloria
A1 Jiménez-Heffernan, José Antonio
A1 Selgas, Rafael
A1 Remón, César
A1 Ossorio, Marta
A1 Fernández-Perpén, Antonio
A1 Sánchez-Tomero, José Antonio
A1 Cirugeda, Antonio
A1 de Sousa, Erika
A1 Sandoval, Pilar
A1 Díaz, Raquel
A1 López-Cabrera, Manuel
A1 Bajo, María Auxiliadora
K1 Peritoneal biopsy
K1 biocompatible dialysis solutions
K1 hyalinizing vasculopathy
K1 mesothelial cell integrity
K1 submesothelial fibrosis
AB ♦ Chronic exposure to conventional peritoneal dialysis (PD) solutions has been related to peritoneal function alterations in PD patients, and associated with mesothelial cell loss, submesothelial fibrosis, vasculopathy, and angiogenesis. In vitro and ex vivo analyses, as well as studies with animal models, have demonstrated that biocompatible PD solutions attenuate these morphological alterations. Our aim was to confirm the morphological benefits of biocompatible solutions in PD patients. ♦ We analyzed biopsies from 23 patients treated with biocompatible solutions (study group, SG), and compared them with a control group (n = 23) treated with conventional solutions (CG), matched for time on PD. ♦ A total of 56.5% of SG patients showed total or partial preservation of mesothelial cells monolayer, in contrast with 26.1% of patients in CG (p = 0.036). Peritoneal fibrosis was not significantly less frequent in SG patients (47.8% SG vs 69.6% CG; p = 0.13). In patients without previous peritonitis, a significantly lower prevalence of fibrosis was present in SG patients (41.7% SG vs 77.8% CG; p = 0.04). Hyalinizing vasculopathy (HV) was significantly lower in SG (4.3% SG vs 30.4% CG; p = 0.02). Cytokeratin-positive fibroblast-like cells were detected in 10 patients (22%), but the prevalence was not significantly lower in SG. In the univariate regression analysis, the use of biocompatible solutions was associated with mesothelial monolayer integrity (p = 0.04) and an absence of vasculopathy (p = 0.04). ♦ The present study demonstrates in vivo in human biopsies that biocompatible solutions are better tolerated by the peritoneum in the medium and long term than conventional solutions.
YR 2015
FD 2015-10-16
LK http://hdl.handle.net/10668/10427
UL http://hdl.handle.net/10668/10427
LA en
DS RISalud
RD Apr 11, 2025