RT Journal Article
T1 Has the COVID-19 pandemic wiped out the seasonality of outpatient antibiotic use and influenza activity? A time-series analysis from 2014 to 2021.
A1 Guisado-Gil, Ana Belén
A1 Benavente, Regina Sandra
A1 Villegas-Portero, Román
A1 Gil-Navarro, María Victoria
A1 Valencia, Raquel
A1 Peñalva, Germán
A1 Cisneros, José Miguel
K1 Antibiotics
K1 COVID-19
K1 Influenza
K1 Outpatient
K1 Prescribing
K1 Primary care
K1 Seasonality
AB To assess the influence of the emergence of severe acute respiratory syndrome coronavirus 2 and the implementation of public health measures on the seasonality of outpatient antibiotic use and their possible association with the incidence of influenza. We performed a time-series ecological study in 1516 primary care centres of Andalusia, Spain, comparing the coronavirus disease 2019 period (April 2020 to March 2021) with the 6 previous years. We assessed the number of packs and defined daily doses per 1000 inhabitants of antibacterials and key antibiotics commonly used for acute respiratory tract infections and the number of influenza-positive cases per 100 000 inhabitants. We calculated the correlation between variables and analyzed the seasonal patterns and differences in quarterly antibiotic use. For all quarters, a significant correlation was observed between influenza activity and antibiotic use (Spearman's r = 0.94; p  The coronavirus disease 2019 pandemic has strongly influenced the seasonality of antibiotic use in primary care. The decline in respiratory viruses, among which the influenza virus is a major player that may act as a proxy for general prevalence, is proposed as a reason for the flattening of the seasonal fluctuations of outpatient antibiotic use in our region.
YR 2022
FD 2022-01-10
LK http://hdl.handle.net/10668/22124
UL http://hdl.handle.net/10668/22124
LA en
DS RISalud
RD Apr 18, 2025