RT Journal Article
T1 Expert Panel Guidance and Narrative Review of Treatment Simplification of Complex Insulin Regimens to Improve Outcomes in Type 2 Diabetes.
A1 Jude, Edward B
A1 Malecki, Maciej T
A1 Gomez-Huelgas, Ricardo
A1 Prazny, Martin
A1 Snoek, Frank
A1 Tankova, Tsvetalina
A1 Giugliano, Dario
A1 Khunti, Kamlesh
K1 Antidiabetic drug
K1 Glycaemic control
K1 Insulin therapy
K1 Primary care
K1 Type 2 diabetes
AB Given the progressive nature of type 2 diabetes (T2D), most individuals with the disease will ultimately undergo treatment intensification. This usually involves the stepwise addition of a new glucose-lowering agent or switching to a more complex insulin regimen. However, complex treatment regimens can result in an increased risk of hypoglycaemia and high treatment burden, which may impact negatively on both therapeutic adherence and overall quality of life. Individuals with good glycaemic control may also be overtreated with unnecessarily complex regimens. Treatment simplification aims to reduce individual treatment burden, without compromising therapeutic effectiveness or safety. Despite data showing that simplifying therapy can achieve good glycaemic control without negatively impacting on treatment efficacy or safety, it is not always implemented in clinical practice. Current clinical guidelines focus on treatment intensification, rather than simplification. Where simplification is recommended, clear guidance is lacking and mostly focused on treatment of the elderly. An expert, multidisciplinary panel evaluated the current treatment landscape with respect to guidance, published evidence, recommendations and approaches regarding simplification of complex insulin regimens. This article outlines the benefits of treatment simplification and provides practical recommendations on simplifying complex insulin treatment strategies in people with T2D using illustrative cases.
PB Springer
SN 1869-6953
YR 2022
FD 2022-03-11
LK http://hdl.handle.net/10668/21363
UL http://hdl.handle.net/10668/21363
LA en
NO Jude EB, Malecki MT, Gomez Huelgas R, Prazny M, Snoek F, Tankova T, et al. Expert Panel Guidance and Narrative Review of Treatment Simplification of Complex Insulin Regimens to Improve Outcomes in Type 2 Diabetes. Diabetes Ther. 2022 Apr;13(4):619-634
DS RISalud
RD Apr 19, 2025