TY - JOUR AU - Cabeza, Laura AU - El-Hammadi, Mazen M. AU - Ortiz, Raul AU - Cayero-Otero, Maria D. AU - Jimenez-Lopez, Julia AU - Perazzoli, Gloria AU - Martin-Banderas, Lucia AU - Baeyens, Jose M. AU - Melguizo, Consolacion AU - Prados, Jose PY - 2022 DO - 10.34172/bi.2022.23433 SN - 2228-5652 UR - http://hdl.handle.net/10668/21817 T2 - Bioimpacts AB - Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious limitations, including lack of tissue-specificity, poor water solubility, and the development of... LA - en PB - Tabriz University of Medical Sciences and Health Services KW - Paclitaxel KW - PLGA KW - Breast cancer KW - Cancer stem cells KW - Mice xenografts KW - Plga-based nanoparticles KW - Albumin-bound paclitaxel KW - Tumor-targeted delivery KW - Drug-delivery KW - In-vitro KW - Intracellular pharmacokinetics KW - Blood-pressure KW - Ovarian-cancer KW - Challenges KW - Women KW - Female KW - Paclitaxel KW - Breast Neoplasms KW - Tubulin KW - Tissue Distribution KW - nile red KW - MCF-7 Cells KW - Solubility KW - Tumor Burden KW - Inhibitory Concentration 50 KW - Spleen KW - Mice, Inbred C57BL KW - Antineoplastic Agents KW - Cell Cycle KW - Lung KW - Drug Resistance KW - Liver KW - Drug Resistance KW - Neoplastic Stem Cells TI - Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer TY - research article ER -