RT Journal Article
T1 Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study.
A1 Dierssen-Sotos, Trinidad
A1 Gómez-Acebo, Inés
A1 Palazuelos, Camilo
A1 Rodriguez-Moranta, Francisco
A1 Pérez-Gómez, Beatriz
A1 Fernández Vazquez, José Pedro
A1 Amiano, Pilar
A1 Barricarte, Aurelio
A1 Mirón-Pozo, Benito
A1 Tardon, Adonina
A1 Capelo, Rocío
A1 Peiro Pérez, Rosana
A1 Huerta, José María
A1 Andreu, Montserrat
A1 Sierra, Mª Ángeles
A1 Castañón López, Carmen
A1 Ruiz, Irune
A1 Moreno-Iribas, Concepción
A1 Olmedo-Requena, Rocío
A1 Castaño-Vinyals, Gemma
A1 Aragonés, Nuria
A1 Kogevinas, Manolis
A1 Pollán, Marina
A1 Llorca, Javier
K1 Angiotensin converting enzyme inhibitor
K1 Angiotensin receptor blocker
K1 Colorectal cancer
AB The potential protective effect of renin-angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2165 cases of colorectal cancer, diagnosed between 2007 and 2012, and 3912 population controls frequency matched (by age, sex and region) from the Spanish multicenter case-control study MCC-Spain. We found a significant protective effect of the angiotensin-converting enzyme Inhibitors (ACEIs) against CRC, limited to the under-65years group (OR=0.65 95%CI (0.48-0.89)) and to a lesser degree to men (OR=0.81 95%CI (0.66-0.99). In contrast, the angiotensin receptor blockers (ARBs) did not show a significant effect. Regarding the duration of use, a greater protection was observed in men as the length of consumption increases. In contrast, in the under-65 stratum, the strongest association was found in short-term treatments. Finally, by analyzing ACEIs effect by colon subsite, we found no differences, except for under 65years old, where the maximum protection was seen in the proximal intestine, descending in the distal and rectum (without statistical significance). In conclusion, our study shows a protective effect on CRC of the ACEis limited to males and people under 65years old, which increases in proximal colon in the latter. If confirmed, these results may suggest a novel approach to proximal CRC prevention, given the shortcomings of colonoscopy screening in this location.
YR 2017
FD 2017-01-26
LK http://hdl.handle.net/10668/10815
UL http://hdl.handle.net/10668/10815
LA en
DS RISalud
RD May 10, 2025