TY  - JOUR
AU  - Prieto-Domínguez, Nestor
AU  - Ordóñez, Raquel
AU  - Fernández, Anna
AU  - García-Palomo, Andres
AU  - Muntané, Jordi
AU  - González-Gallego, Javier
AU  - Mauriz, José L
PY  - 2016
DO  - 10.3389/fphar.2016.00151
UR  - http://hdl.handle.net/10668/2535
T2  - Frontiers in Pharmacology
AB  - The multikinase inhibitor sorafenib is, at present, the only drug approved for the treatment of hepatocellular carcinoma (HCC), one of the most lethal types of cancer worldwide. However, the increase in the number of sorafenib tumor resistant cells...
LA  - en
PB  - Frontiers Media
KW  - Autophagy
KW  - Cancer therapeutic
KW  - Dug resistance
KW  - Hepatocellular carcinoma
KW  - Sorafenib
KW  - Proteínas quinasas activadas por AMP
KW  - Carcinoma hepatocelular
KW  - Supervivencia celular
KW  - Neoplasias hepáticas
KW  - Células mieloides
KW  - Compuestos de fenilurea
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::AMP-Activated Protein Kinases
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Autophagy
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Hepatocellular
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
KW  - Medical Subject Headings::Anatomy::Cells::Myeloid Cells
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Acids, Heterocyclic::Nicotinic Acids::Niacinamide
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Urea::Phenylurea Compounds
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Sirolimus
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::TOR Serine-Threonine Kinases
TI  - Modulation of Autophagy by Sorafenib: Effects on Treatment Response.
TY  - review article
ER  -