RT Journal Article
T1 No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis.
A1 Cénit, María Carmen
A1 Márquez, Ana
A1 Cordero-Coma, Miguel
A1 Gorroño-Echebarría, Marina Begoña
A1 Fonollosa, Alejandro
A1 Adán, Alfredo
A1 Martínez-Berriotxoa, Agustín
A1 Díaz Valle, David
A1 Pato, Esperanza
A1 Blanco, Ricardo
A1 Cañal, Joaquín
A1 Díaz-Llopis, Manuel
A1 García Serrano, José Luis
A1 de Ramón, Enrique
A1 Del Rio, María José
A1 Martín-Villa, José Manuel
A1 Molins, Blanca
A1 Ortego-Centeno, Norberto
A1 Martín, Javier
K1 Receptors, Interleukin
K1 STAT4 Transcription Factor
K1 IL23R protein, human
K1 Alelos
K1 Autoinmunidad
K1 Genotipo
K1 Polimorfismo genético
K1 Polimorfismo de nucleótido simple
K1 Receptores de interleucina
K1 Factores de transcripción
K1 Uveítis
AB OBJECTIVE: STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. We decided to investigate for the first time the possible role of different STAT4/IL23R autoimmune disease-associated polymorphisms on the susceptibility to develop non-anterior uveitis and its main clinical phenotypes.METHODSFour functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain.RESULTSNo statistically significant differences were found when allele and genotype distributions were compared between non-anterior uveitis patients and controls for any STAT4 (rs3821236: P=0.39, OR=1.12, CI 95%=0.87-1.43; rs7574865: P=0.59 OR=1.07, CI 95%=0.84-1.37; rs7574070: P=0.26, OR=0.89, CI 95%=0.72-1.10; rs897200: P=0.22, OR=0.88, CI 95%=0.71-1.08;) or IL23R polymorphisms (rs7517847: P=0.49, OR=1.08, CI 95%=0.87-1.33; rs11209026: P=0.26, OR=0.78, CI 95%=0.51-1.21; rs1495965: P=0.51, OR=0.93, CI 95%=0.76-1.15).CONCLUSIONOur results do not support a relevant role, similar to that described for other autoimmune diseases, of IL23R and STAT4 polymorphisms in the non-anterior uveitis genetic predisposition. Further studies are needed to discard a possible weak effect of the studied variant.
PB Public Library of Science
YR 2013
FD 2013
LK http://hdl.handle.net/10668/1987
UL http://hdl.handle.net/10668/1987
LA en
NO Cénit MC, Márquez A, Cordero-Coma M, Gorroño-Echebarría MB, Fonollosa A, Adán A, et al. No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis. PLoS ONE. 2013, 8(11):e72892
NO Journal Article;
DS RISalud
RD Apr 18, 2025